Nitric Oxide / Cyclic Nucleotide Regulation of Globin Genes in Erythropoiesis
نویسندگان
چکیده
Vladan P. Čokić1, Bojana B. Beleslin-Čokić2, Gordana Jovčić1, Raj K. Puri3 and Alan N. Schechter4 1Laboratory of Experimental Hematology, Institute for Medical Research, Belgrade, 2Clinic of Endocrinology, Diabetes and Diseases of Metabolism, School of Medicine, University Clinical Center, Belgrade, 3Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, 4Molecular Medicine Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, 1,2Serbia 3,4USA
منابع مشابه
Complex signatures of selection and gene conversion in the duplicated globin genes of house mice.
Results of electrophoretic surveys have suggested that hemoglobin polymorphism may be maintained by balancing selection in natural populations of house mice, Mus musculus. Here we report a survey of nucleotide variation in the adult globin genes of house mice from South America. We surveyed nucleotide polymorphism in two closely linked alpha-globin paralogs and two closely linked beta-globin pa...
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Much attention has been directed to the physiological effects of nitric oxide (NO)-cGMP signaling, but virtually nothing is known about its hematologic effects. We reported for the first time that cGMP signaling induces human γ-globin gene expression. Aiming at developing novel therapeutics for anemia, we examined here the hematologic effects of NO-cGMP signaling in vivo and in vitro. We treate...
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b-hemoglobinopathies are inherited disorders caused by mutations/ deletions in theb-globin chain that lead to structurallydefectiveb-globin chains or reduced (or absent) b-globin chain production. These diseases affect multiple organs and are associated with considerable morbidity andmortality, representing amajor public health challenge. Hydroxyurea (HU) has been successfully used in the treat...
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Human β-globin gene expression is regulated tightly during development and hematopoiesis. The human β-globin locus comprises five developmentally regulated genes (5′-ε-Gγ-Aγ-δ-β-3′) whose high level and stage-specific expression depends on interactions with the locus control region (LCR), consisting of five major DNaseI hypersensitive sites (Figure 1). The LCR activates β-globin gene transcript...
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F if any, proteins have been studied in as many organisms as have the hemoglobins. They are found in bacteria, fungi, plants, and animals, serving physiological roles ranging from oxygen transport in the blood of vertebrates to catalyzing the combination of oxygen and nitric oxide to form nitrate in bacteria, yeast, and worms (1, 2). Hence hemoglobins and the globin genes encoding them have bee...
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